منابع مشابه
Signal integration at the c-fos promoter.
The c-fos gene encodes a basic region-leucine zipper transcription factor that requires heterodimerization with a member of the Jun family for stable DNA binding. Fos/Jun heterodimers are present in the AP-1 transcription factor complex and both c-Fos and c-Jun are capable of transforming cells (1). Continuous expression of c-fos can lead to aberrant differentiation (2) but may also sometimes b...
متن کاملExtracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter.
We have previously shown that TFII-I enhances transcriptional activation of the c-fos promoter through interactions with upstream elements in a signal-dependent manner. Here we demonstrate that activated Ras and RhoA synergize with TFII-I for c-fos promoter activation, whereas dominant-negative Ras and RhoA inhibit these effects of TFII-I. The Mek1 inhibitor, PD98059 abrogates the enhancement o...
متن کاملSignal integration by the CYP1A1 promoter — a quantitative study
Genes involved in detoxification of foreign compounds exhibit complex spatiotemporal expression patterns in liver. Cytochrome P450 1A1 (CYP1A1), for example, is restricted to the pericentral region of liver lobules in response to the interplay between aryl hydrocarbon receptor (AhR) and Wnt/β-catenin signaling pathways. However, the mechanisms by which the two pathways orchestrate gene expressi...
متن کاملDNA bending and orientation-dependent function of YY1 in the c-fos promoter.
The assembly of multicomponent complexes at promoters, enhancers, and silencers likely entails perturbations in the path of the DNA helix. We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos promoter primarily through an effect on DNA structure. YY1 binds to and induces a phased DNA bend at three sites in this promoter. By use of a tru...
متن کاملCell-specific regulation of oncogene-responsive sequences of the c-fos promoter.
We have identified oncogene-responsive sequences in the human c-fos promoter that mediate induction of transcription by several nonnuclear oncoproteins and the tumor promoter TPA. These sequences are regulated in a cell-specific manner. (i) In NIH 3T3 cells, the CArG box of the c-fos promoter is sufficient to mediate activation by oncogenes. (ii) In contrast, in HeLa cells, additional flanking ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1995
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/16.3.443